HGH is large, fragile protein molecule with a molecular weight of 20,000. It contains 191 amino acids in an exact sequence. Its only source is from human genes, using very expensive and meticulous recombinant DNA technology. HGH from any other source, even from other animals, does not work in humans. There is no other source of HGH. There is absolutely no naturally occurring plant source of HGH. HGH must be made using human genetics. The only safe form of HGH is made by splicing human genes into cells and then multiplying those cells in a culture media.
A protein molecule that large cannot penetrate intact membranes to any significant degree. Most would be wasted if it were used in a nasal spray or orally. Manufacturing costs are high. HGH is so expensive that any waste is prohibitively expensive.
The technology to make HGH is patented by large pharmaceutical companies and is restricted by law to their use.
The HGH molecule loses potency very rapidly when dissolved in solution. The molecule is folded and twisted on itself repeatedly. Activity in the body depends on fragile cross linkages between branches of this very large molecule, which hold it in an exact three-dimensional configuration. It works on cell receptors exactly like a key in a lock. Any change in shape blocks HGH activity, even if the chemical formula remains exactly the same. Those cross-linkages break very easily and become unstable soon after dissolving in solution. Only with refrigeration can biological activity be maintained for up to two weeks. That's how fragile the molecule is. How then could activity be maintained in a liquid spray?
For storage and shipping, HGH must be very carefully freeze-dried under a vacuum to become a powder. From most manufacturers even the powder must also be kept refrigerated to maintain activity. Only one large pharmaceutical company with research budgets in the billions of dollars has been able to solve that problem.
HGH is classified as a pharmaceutical drug, strictly controlled by the FDA under state and federal laws and regulations. It is illegal to sell, prescribe, or dispense HGH except through a licensed pharmacy or clinic, and then only on a doctor's prescription in a bone fide doctor-patient relationship. To do otherwise is a criminal offense under the law.
Research studies proving benefit and safety have been published only for the injectable freeze-dried powder form of rHGH, taken by injection soon after dissolving in solution.
COMMENTS ON "FACT" SHEETS ACCOMPANYING SOME SUCH PRODUCTS
CLAIM: This is the first orally absorbed HGH, 191 amino acids (protein molecules) which are transported by a proprietary polymer matrix, allowing it to be absorbed in the oral mucosa and then transported directly to the Pituitary Gland.
COMMENT: HGH has no beneficial effect at the pituitary gland. HGH has its effect elsewhere in the body. After entering the bloodstream, HGH very quickly attaches to receptors on trillions of cells through out the body. The pituitary gland is the normal source of HGH in young adults. The pituitary releases HGH into the circulation so that it can have it's effects elsewhere.
CLAIM: The oral spray avoids inactivation by the liver.
COMMENT: When HGH is absorbed through the mucous membranes of the mouth or by injection it is handled in exactly the same way by the body. Only if absorbed through the lower intestine, as food is, would it go to the liver first through the portal venous system.
CLAIM: Until now, it has been virtually impossible to achieve oral absorption of the large HGH molecule. Previously, the only way was through injection into the bloodstream.
COMMENT: Using patented technology, the pharmaceutical industry has developed ways to partially absorb some drugs through the skin. But only for small, non-protein molecules. Insulin is a protein molecule only half as large as HGH. If it were possible to absorb that kind of hormone by mouth, by spray, or through membranes, millions of people with diabetes would not need to take insulin by injection. The millions of dollars spent on research to do just that has been unsuccessful.
CLAIM: HGH Oral Spray vs. Injections? An injection of one international unit (i.u.) is equivalent to 250,000 nanograms (parts per billion).
COMMENT: Aproximately 350,000 nanograms (0.375 milligrams) equals one unit of HGH. A 4-unit vial contains approx. 1.52 mg pure HGH (1,520,000 nanograms).
CLAIM: Injected HGH goes into the bloodstream and is absorbed by the liver.
COMMENT: Some HGH is always taken up by the liver because part of its activity is in the liver. Otherwise, it would be less effective. However, the ultimate distribution of HGH would be exactly the same through oral or nasal tissues by spray (if that were possible) as it is by injection.
CLAIM: Any excess BY INJECTION is destroyed or diluted in the blood.
COMMENT: The half-life of HGH is only a few seconds after release by the pituitary or by injection. However, it is not destroyed. It must be very rapidly attach to hormone receptors on cells throughtout the body to have its effects. It is not wasted. It attaches to trillions of cells in the body, all types of cells, within a few seconds where it has its benefit. That takes only a few seconds. It is not destroyed, but utilitzed. If HGH does not dilute in the blood to spread throughtout the body, it has no effect.
CLAIM: There is no over stimulation of HGH by the spray.
COMMENT: This claim makes no sense. HGH does not stimulate HGH, it replaces lost production. The daily production of a 20-year-old is about 500,000 nanograms per day. In a 75-year-old it's about 100,000. The goal is to replace HGH back up to 500,000 nanograms per day.
CLAIM: Compared to the spray, others products are secretagogues, precursors and stimulants, with limited potential for increasing HGH.
COMMENT: It's true that most products being marketed as nutritional supplements or secretagogues have limited potential for increasing HGH. How a spray can be any different is the unanswered question?
Some secretagogues sold as nutritional supplements may be able to increase pituitary HGH release by at up to 30%, if taken in very large doses on a totally empty stomach. A 65-year-old person with only 30% remaining does not get much from a 30% increase (that only increases to less than 40% of a desired level). And, the dose required to do that is quite expensive.
CLAIM: What is HGH Oral Spray made from? This signal messenger hormone is a plant-based all natural product made form microorganisms. There are no animal products used, only HGH and other minerals.
COMMENT: Then there is no HGH in the product. HGH stands for "human" growth hormone. It exists in no other species of plant or animal.
CLAIM: Have any results been proven? Positive results have been proven in 75% of tested cases (three out of four people).
COMMENT: Then let's see tabulated objective benefits, measured in a clinical study--not just blanket statements, testimonials and marketing claims made by those who stand to profit from sales. Where is the research data?
The Following Have Been Proven By Objective Measurement In Scientific Studies Published In Peer-Reviewed Scientific Journals, But Only With The Injected True HGH.
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15% average decrease in fat
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8% average increase in muscle and lean body structures
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Improved skin texture resulting in a more youthful appearance.
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Skin 7% thicker
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Fewer skin wrinkles
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Increased bone density, reversal of osteoporosis
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Faster healing of any type of injury, fracture or wound
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Greatly enhanced immunity and resistance to infection
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Enhanced brain function, retention of intellect with aging
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Improved sex drive
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Improvement in overall physical and mental well being
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Improvement in sleep disorders, better quality of sleep
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Improved exercise tolerance
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Improved mineral balance
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Improved mood, with less depression and fatigue
NONE OF THOSE BENEFITS HAVE BEEN OBJECTIVELY MEASURED WITH ORAL TABLETS, CAPSULES OR SPRAYS.
CLAIM: This stimulating dose works by being absorbed into the feedback system of the Pituitary Gland.
COMMENT: This is a nonsense statement, seemingly meant to deceive scientifically unsophisticated consumers.
CLAIM: FDA approval is not needed. This is a dietary supplement and not a drug. Therefore, under the dietary supplement of DSHEA act, it does no have to be FDA approved.
COMMENTS: If it contains HGH, then it is FDA regulated by law! If it is not FDA regulated it is because it does not contain HGH.
CLAIM: It acts as a master balancer for the body. It regenerates and helps to repair the body.
COMMENT: True only for the real injected form of HGH in doses of 300,000 nanograms or more per day.
